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At Spero Therapeutics, Inc.'s shareholder meeting held June 23, 2026, in the 2025-2026 proxy season, 50 asset managers reported how they voted in their SEC Form N-PX filings, covering 205 separate fund positions. Their filings are grouped here into 7 reported items; because filers word the same ballot item differently, that can be more than the number of items on the ballot. No official Form 8-K vote tally has been matched to this meeting, so this page states no certified outcome for its most widely held ballot item. On that item — To approve by an advisory vote the compensation of the Company's named executive officers, as… — the reporting funds and managers cast 99.5% of the shares they voted in favour (FOR divided by FOR plus AGAINST plus WITHHELD; abstained and unvoted shares are excluded because neither took a side). Fund and manager reports are combined in it and may count the same shares twice: it adds fund reports to institutional-manager reports, which can cover the same shares. It is not the company's certified result.
Download data (CSV): ballot items · votes by manager · column guide.
Compiled from SEC Form N-PX filings. Page generated November 8, 2026.
No official results are on file for this meeting: no Form 8-K tally (Item 5.07) from Spero Therapeutics, Inc. has been matched to it. The figures below are the funds’ own votes from Form N-PX. They are not the meeting result, so they are not used to judge dissent.
Material dissent: a director nominee under 80% of the votes cast, say-on-pay under 70%, any other item the board put forward under 80%, or a shareholder proposal with more than 50%, on the company’s own Form 8-K tally. How this is decided
Proxy season: 2023-2024 2025-2026
Explore Spero Therapeutics, Inc. in the interactive database Compare manager voting policies
Each item below shows how the 50 asset managers that disclosed a Spero Therapeutics, Inc. vote in their SEC Form N-PX filings actually voted. Share totals are the shares those managers' funds voted, summed across every fund they report. These are reported items, not a count of the ballot: fund filings describe one ballot item in different words. Two descriptions are shown as one item only on evidence — the same text (or one cut short of the other), the same director nominee, or a match to the same row of Spero Therapeutics, Inc.’s own Form 8-K tally — never because they merely read alike. A description that could not be joined that way is listed on its own, so one ballot item can appear more than once.
Combines 3 wordings of this item as funds reported it.
99.0% of fund votes cast · no official result
Description as filed by funds: To elect two Class III directors to serve until the Company's 2029 Annual Meeting of Stockholders or until their respective successors are elected and qualified: Kathleen Tregoning
The 11 asset managers below reported 2,433,017 for, 24,498 withheld, 3 abstained. The figure above is FOR ÷ (FOR + AGAINST + WITHHELD) of the shares these managers voted; abstained and unvoted shares are in neither half, and these managers are a subset of all shareholders, not the meeting result.
| Asset manager | For | Against | Abstain | Withheld | Vote |
|---|---|---|---|---|---|
| Vanguard | 1,772,010 | 0 | 3 | 3,690 | For |
| Fidelity | 435,968 | 0 | 0 | 0 | For |
| BRIDGEWAY FUNDS INC | 114,800 | 0 | 0 | 0 | For |
| Invesco | 46,206 | 0 | 0 | 0 | For |
| Charles Schwab | 28,565 | 0 | 0 | 0 | For |
| Dimensional | 0 | 0 | 0 | 20,808 | Withhold |
| American Century | 18,754 | 0 | 0 | 0 | For |
| Northern Trust | 6,106 | 0 | 0 | 0 | For |
| Blackstone Alternative Investment Funds | 5,800 | 0 | 0 | 0 | For |
| Victory Capital | 4,664 | 0 | 0 | 0 | For |
| Guggenheim | 144 | 0 | 0 | 0 | For |
Combines 3 wordings of this item as funds reported it.
93% of fund votes cast · no official result
Description as filed by funds: To elect two Class III directors to serve until the Company's 2029 Annual Meeting of Stockholders or until their respective successors are elected and qualified: Milind Deshpande, Ph.D.
The 11 asset managers below reported 2,282,745 for, 174,766 withheld, 7 abstained. The figure above is FOR ÷ (FOR + AGAINST + WITHHELD) of the shares these managers voted; abstained and unvoted shares are in neither half, and these managers are a subset of all shareholders, not the meeting result.
| Asset manager | For | Against | Abstain | Withheld | Vote |
|---|---|---|---|---|---|
| Vanguard | 1,772,006 | 0 | 7 | 3,690 | For |
| Fidelity | 435,968 | 0 | 0 | 0 | For |
| BRIDGEWAY FUNDS INC | 0 | 0 | 0 | 114,800 | Withhold |
| Invesco | 46,206 | 0 | 0 | 0 | For |
| Charles Schwab | 28,565 | 0 | 0 | 0 | For |
| Dimensional | 0 | 0 | 0 | 20,808 | Withhold |
| American Century | 0 | 0 | 0 | 18,754 | Withhold |
| Northern Trust | 0 | 0 | 0 | 6,106 | Withhold |
| Blackstone Alternative Investment Funds | 0 | 0 | 0 | 5,800 | Withhold |
| Victory Capital | 0 | 0 | 0 | 4,664 | Withhold |
| Guggenheim | 0 | 0 | 0 | 144 | Withhold |
99.8% of fund votes cast · no official result
Description as filed by funds: To approve an amendment to the Company's Amended and Restated Certificate of Incorporation to increase the total number of shares of common stock authorized for issuance thereunder from 120,000,000 shares to 240,000,000 shares.
The 11 asset managers below reported 2,453,794 for, 3,724 against. The figure above is FOR ÷ (FOR + AGAINST + WITHHELD) of the shares these managers voted; abstained and unvoted shares are in neither half, and these managers are a subset of all shareholders, not the meeting result.
| Asset manager | For | Against | Abstain | Withheld | Vote |
|---|---|---|---|---|---|
| Vanguard | 1,771,979 | 3,724 | 0 | 0 | For |
| Fidelity | 435,968 | 0 | 0 | 0 | For |
| BRIDGEWAY FUNDS INC | 114,800 | 0 | 0 | 0 | For |
| Invesco | 46,206 | 0 | 0 | 0 | For |
| Charles Schwab | 28,565 | 0 | 0 | 0 | For |
| Dimensional | 20,808 | 0 | 0 | 0 | For |
| American Century | 18,754 | 0 | 0 | 0 | For |
| Northern Trust | 6,106 | 0 | 0 | 0 | For |
| Blackstone Alternative Investment Funds | 5,800 | 0 | 0 | 0 | For |
| Victory Capital | 4,664 | 0 | 0 | 0 | For |
| Guggenheim | 144 | 0 | 0 | 0 | For |
91% of fund votes cast · no official result
The 12 asset managers below reported 2,236,576 for, 220,983 against. The figure above is FOR ÷ (FOR + AGAINST + WITHHELD) of the shares these managers voted; abstained and unvoted shares are in neither half, and these managers are a subset of all shareholders, not the meeting result.
| Asset manager | For | Against | Abstain | Withheld | Vote |
|---|---|---|---|---|---|
| Vanguard | 1,772,002 | 3,701 | 0 | 0 | For |
| Fidelity | 435,968 | 0 | 0 | 0 | For |
| BRIDGEWAY FUNDS INC | 0 | 114,800 | 0 | 0 | Against |
| Invesco | 0 | 46,206 | 0 | 0 | Against |
| Charles Schwab | 28,565 | 0 | 0 | 0 | For |
| Dimensional | 0 | 20,808 | 0 | 0 | Against |
| American Century | 0 | 18,754 | 0 | 0 | Against |
| Northern Trust | 0 | 6,106 | 0 | 0 | Against |
| Blackstone Alternative Investment Funds | 0 | 5,800 | 0 | 0 | Against |
| Victory Capital | 0 | 4,664 | 0 | 0 | Against |
| Guggenheim | 0 | 144 | 0 | 0 | Against |
| Rangeley Capital, LLC | 41 | 0 | 0 | 0 | For |
99.5% Fund and manager reports combined; may count the same shares twice · no official result
Description as filed by funds: To approve by an advisory vote the compensation of the Company's named executive officers, as disclosed in the proxy statement.
Fund voting reports and institutional-manager reports both cover this item. An institutional manager can report shares that a fund it advises also reports, so the two are shown separately below and never added together, and their sum is not shown (fund and manager reports combined may count the same shares twice). The figure above is FOR ÷ (FOR + AGAINST + WITHHELD) of the shares these managers voted; abstained and unvoted shares are in neither half, and these managers are a subset of all shareholders, not the meeting result.
| Asset manager | For | Against | Abstain | Withheld | Vote |
|---|---|---|---|---|---|
| Vanguard | 1,775,700 | 3 | 0 | 0 | For |
| Fidelity | 435,968 | 0 | 0 | 0 | For |
| BRIDGEWAY FUNDS INC | 114,800 | 0 | 0 | 0 | For |
| Invesco | 46,206 | 0 | 0 | 0 | For |
| Charles Schwab | 28,565 | 0 | 0 | 0 | For |
| Dimensional | 20,808 | 0 | 0 | 0 | For |
| American Century | 0 | 18,754 | 0 | 0 | Against |
| Northern Trust | 6,106 | 0 | 0 | 0 | For |
| Blackstone Alternative Investment Funds | 5,800 | 0 | 0 | 0 | For |
| Victory Capital | 4,664 | 0 | 0 | 0 | For |
| Guggenheim | 144 | 0 | 0 | 0 | For |
Fund voting reports, all 11 managers: 2,438,761 for, 18,757 against.
| Asset manager | For | Against | Abstain | Withheld | Vote |
|---|---|---|---|---|---|
| PFIZER INC | 2,362,348 | 0 | 0 | 0 | For |
| GV Management Company, L.L.C. | 889,979 | 0 | 0 | 0 | For |
| GEODE CAPITAL MANAGEMENT, LLC | 538,208 | 0 | 0 | 0 | For |
| Renaissance | 516,308 | 0 | 0 | 0 | For |
| BlackRock | 345,201 | 0 | 0 | 0 | For |
| Two Sigma | 301,262 | 0 | 0 | 0 | For |
| Vanguard | 290,431 | 0 | 0 | 0 | For |
| State Street | 152,351 | 0 | 0 | 0 | For |
| MARSHALL WACE, LLP | 145,452 | 0 | 0 | 0 | For |
| Northern Trust | 118,758 | 0 | 0 | 0 | For |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 114,800 | 0 | 0 | 0 | For |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 93,506 | 0 | 0 | 0 | For |
| Hillsdale Investment Management Inc. | 70,856 | 0 | 0 | 0 | For |
| Invesco | 64,842 | 0 | 0 | 0 | For |
| Point72 | 41,122 | 0 | 0 | 0 | For |
| Charles Schwab | 28,565 | 0 | 0 | 0 | For |
| American Century | 0 | 18,754 | 0 | 0 | Against |
| Fisher Asset Management, LLC | 14,645 | 0 | 0 | 0 | For |
| Citadel | 9,163 | 0 | 0 | 0 | For |
| MELLON INVESTMENTS Corp | 8,358 | 0 | 0 | 0 | For |
| Dimensional | 8,186 | 0 | 0 | 0 | For |
| Edward D. Jones & Co., L.P. | 7,678 | 0 | 0 | 0 | For |
| FERGUSON WELLMAN CAPITAL MANAGEMENT, INC | 7,500 | 0 | 0 | 0 | For |
| Victory Capital | 4,664 | 0 | 0 | 0 | For |
| RBC Capital Markets, LLC | 3,500 | 0 | 0 | 0 | For |
Institutional-manager reports, all 44 managers: 6,146,869 for, 18,754 against. Showing the 25 largest; every one is in the interactive database (link above).
— of fund votes cast · no official result
The 2 asset managers below reported 720 not voted.
| Asset manager | For | Against | Abstain | Withheld | Vote |
|---|---|---|---|---|---|
| Impact Investors, Inc | 0 | 0 | 0 | 0 | Not Voted |
| Torrey Growth & Income Advisors | 0 | 0 | 0 | 0 | -- |
100% of fund votes cast · no official result
Description as filed by funds: To ratify the appointment of PricewaterhouseCoopers LLP as the Company's independent registered public accounting firm for the fiscal year ending December 31, 2026.
The 11 asset managers below reported 2,457,519 for. The figure above is FOR ÷ (FOR + AGAINST + WITHHELD) of the shares these managers voted; abstained and unvoted shares are in neither half, and these managers are a subset of all shareholders, not the meeting result.
| Asset manager | For | Against | Abstain | Withheld | Vote |
|---|---|---|---|---|---|
| Vanguard | 1,775,704 | 0 | 0 | 0 | For |
| Fidelity | 435,968 | 0 | 0 | 0 | For |
| BRIDGEWAY FUNDS INC | 114,800 | 0 | 0 | 0 | For |
| Invesco | 46,206 | 0 | 0 | 0 | For |
| Charles Schwab | 28,565 | 0 | 0 | 0 | For |
| Dimensional | 20,808 | 0 | 0 | 0 | For |
| American Century | 18,754 | 0 | 0 | 0 | For |
| Northern Trust | 6,106 | 0 | 0 | 0 | For |
| Blackstone Alternative Investment Funds | 5,800 | 0 | 0 | 0 | For |
| Victory Capital | 4,664 | 0 | 0 | 0 | For |
| Guggenheim | 144 | 0 | 0 | 0 | For |
Ranked separately for each type of Form N-PX report. An institutional manager can report shares that a fund it advises also reports, so the two tables can list the same shares and are never added together. Each is ranked by the shares voted on the item that the most managers of that type reported, shown as a share of the 57,901,493 shares outstanding at the time of that meeting.
| # | Asset manager | % of shares outstanding |
|---|---|---|
| 1 | Vanguard | 3.07% |
| 2 | Fidelity | 0.75% |
| 3 | BRIDGEWAY FUNDS INC | 0.20% |
| 4 | Invesco | 0.08% |
| 5 | Charles Schwab | 0.05% |
| 6 | Dimensional | 0.04% |
| 7 | American Century | 0.03% |
| 8 | Northern Trust | 0.01% |
| 9 | Blackstone Alternative Investment Funds | 0.01% |
| 10 | Victory Capital | <0.01% |
| # | Asset manager | % of shares outstanding |
|---|---|---|
| 1 | PFIZER INC | 4.08% |
| 2 | GV Management Company, L.L.C. | 1.54% |
| 3 | GEODE CAPITAL MANAGEMENT, LLC | 0.93% |
| 4 | Renaissance | 0.89% |
| 5 | BlackRock | 0.60% |
| 6 | Two Sigma | 0.52% |
| 7 | Vanguard | 0.50% |
| 8 | State Street | 0.26% |
| 9 | MARSHALL WACE, LLP | 0.25% |
| 10 | Northern Trust | 0.21% |
As disclosed to the SEC in Form 13F (quarter-end holdings of 30 large managers), Schedules 13D and 13G (beneficial ownership above 5%) and the company’s own proxy statement (DEF 14A). Each row names its form.
| Holder | % outstanding | Disclosure |
|---|---|---|
| GSK plc | 15.87% | DEF14A |
| Vanguard Group | 3.60% | 13F |
| Renaissance Technologies | 2.05% | 13F |
| Two Sigma | 1.53% | 13F |
| Timothy Keutzer | 1.05% | DEF14A |
| Geode Capital | 0.90% | 13F |
| BlackRock | 0.75% | 13F |
| Citadel Advisors | 0.74% | 13F |
| Esther Rajavelu | 0.44% | DEF14A |
| State Street | 0.37% | 13F |
Percentages above are of 57,901,493 shares outstanding, as reported by Spero Therapeutics, Inc. on its Form 10-Q dated May 1, 2026 (see the filing on EDGAR). This is the count contemporaneous with the 2025-2026 meeting, not today’s. Each holding is as of its own filing, which may be dated before or after the meeting.
Every figure above is derived from filings made with the US Securities and Exchange Commission: Form N-PX, in which registered funds disclose how they voted every proxy and institutional managers disclose their votes on executive pay (say-on-pay, say-on-frequency and golden parachutes), and Form 8-K Item 5.07, in which the company reports its own meeting results. Shares outstanding are taken from Spero Therapeutics, Inc.’s 10-Q dated May 1, 2026. This page is a static snapshot rebuilt weekly on November 8, 2026; a live search always shows the current data.
Spero Therapeutics, Inc. proxy season coverage: 2023-2024 · 2025-2026 (this page).
proxyvotesnow.com, “Spero Therapeutics (SPRO) 2026 Annual Meeting: Vote Results”, https://proxyvotesnow.com/company/spero-therapeutics-inc/2026 (version of November 9, 2026). Derived from SEC Form N-PX and Form 8-K filings; tables licensed CC BY 4.0. Licence: CC BY 4.0.