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Compiled from SEC Form N-PX filings and SPYRE THERAPEUTICS INC.’s Form 8-K, filed 2025-06-02 (Item 5.07 on EDGAR). Page generated 04 October 2026.
Proxy season: 2024-2025 2025-2026
Explore SPYRE THERAPEUTICS INC. in the interactive database Compare manager voting policies
These tallies are SPYRE THERAPEUTICS INC.’s own, as disclosed to the U.S. Securities and Exchange Commission on Form 8-K, filed 2025-06-02 (Item 5.07, “Submission of Matters to a Vote of Security Holders”). They cover every share voted at the meeting, not just the funds that file Form N-PX.
| Ballot item | For | Against | Abstain | Withheld | Broker non-votes | Outcome |
|---|---|---|---|---|---|---|
| Elect Director: Peter Harwin | 38,196,060 | -- | -- | 7,977,323 | 3,120,432 | Majority: yes |
| Elect Director: Michael Henderson, M.D. | 45,441,918 | -- | -- | 731,465 | 3,120,432 | Majority: yes |
| Elect Director: Sandra Milligan, M.D., J.D. | 37,612,795 | -- | -- | 8,560,588 | 3,120,432 | Majority: yes |
| Proposal 2: The Company's stockholders approved, on a non-binding, advisory basis, the compensation of the Company's named executive officers. | 42,930,720 | 3,144,040 | 98,623 | -- | 3,120,432 | Majority: yes |
| Proposal 3: The Company's stockholders ratified the appointment of KPMG LLP as the Company's independent registered public accounting firm for the year ending December 31, 2025. | 49,227,863 | 57,123 | 8,829 | -- | 0 | Majority: yes |
Source: SPYRE THERAPEUTICS INC., Form 8-K, filed with the SEC on 2025-06-02 — read the filing on EDGAR.
Each item below shows how the 152 asset managers that disclosed a SPYRE THERAPEUTICS INC. vote in their SEC Form N-PX filings actually voted. Share totals are the shares those managers' funds voted, summed across every fund they report.
Combines 7 wordings of this item as funds reported it.
93% Majority: yes · of votes cast
SPYRE THERAPEUTICS INC.’s own tally for this item (“Proposal 2: The Company's stockholders approved, on a non-binding, advisory basis, the compensation of the Company's named executive officers.”): 42,930,720 for, 3,144,040 against, per its Form 8-K filed 2025-06-02 (Item 5.07). FOR was more than half of the votes cast. Whether the item passed is for the filing to say; its statement has not been read for this item. Of all 60,275,561 outstanding shares: 71% for, 5% against (76% of the company cast a for/against vote).
The 152 asset managers below cast 89% of the shares they voted on this item FOR. Fund share totals are not shown for this item: fund-reported shares overlap across filings (an adviser and the funds it manages can each report the same shares), and here their sum exceeds the total votes cast at the meeting.
| Asset manager | For | Against | Abstain | Withheld | Vote |
|---|---|---|---|---|---|
| Fidelity | 13,599,586 | 0 | 0 | 0 | For |
| Capital Group | 0 | 5,483,356 | 0 | 0 | Against |
| Fairmount Funds Management LLC | 4,018,101 | 0 | 0 | 0 | For |
| RTW INVESTMENTS, LP | 3,583,727 | 0 | 0 | 0 | For |
| Vanguard | 2,926,714 | 0 | 0 | 0 | For |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,856,436 | 0 | 0 | 0 | For |
| BlackRock | 1,615,079 | 606 | 0 | 0 | For |
| PERCEPTIVE ADVISORS LLC | 1,311,814 | 0 | 0 | 0 | For |
| BRAIDWELL LP | 1,139,682 | 0 | 0 | 0 | For |
| GEODE CAPITAL MANAGEMENT, LLC | 1,049,384 | 0 | 0 | 0 | For |
| State Street | 1,010,943 | 138 | 0 | 0 | For |
| Commodore Capital LP | 1,010,289 | 0 | 0 | 0 | For |
| PICTET ASSET MANAGEMENT SA | 983,369 | 0 | 0 | 0 | For |
| Wellington | 917,657 | 0 | 0 | 0 | For |
| Charles Schwab | 764,300 | 0 | 0 | 0 | For |
| FRANKLIN ADVISERS INC | 760,615 | 0 | 0 | 0 | For |
| Paradigm Biocapital Advisors LP | 630,473 | 0 | 0 | 0 | For |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 613,665 | 0 | 0 | 0 | For |
| Janus Henderson | 591,627 | 0 | 0 | 0 | For |
| Bridge Builder Trust | 485,827 | 0 | 0 | 0 | For |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 460,400 | 0 | 0 | 0 | For |
| Victory Capital | 390,417 | 0 | 0 | 0 | For |
| T. Rowe Price | 386,829 | 0 | 0 | 0 | For |
| Blackstone Inc. | 374,299 | 0 | 0 | 0 | For |
| EMERALD MUTUAL FUND ADVISERS TRUST | 351,604 | 0 | 0 | 0 | For |
Showing the 25 largest of 152 asset managers. See all 152 in the interactive database.
Combines 4 wordings of this item as funds reported it.
98% Majority: yes · of votes cast
SPYRE THERAPEUTICS INC.’s own tally for this item (“Elect Director: Michael Henderson, M.D.”): 45,441,918 for, 731,465 withheld, per its Form 8-K filed 2025-06-02 (Item 5.07). FOR was more than half of the votes cast. Whether the item passed is for the filing to say; its statement has not been read for this item. Of all 60,275,561 outstanding shares: 75% for, 1% withheld (77% of the company cast a for/withheld vote).
The 52 asset managers below cast 100% of the shares they voted on this item FOR (14,802,981 for, 0 against).
| Asset manager | For | Against | Abstain | Withheld | Vote |
|---|---|---|---|---|---|
| Fidelity | 5,935,483 | 0 | 0 | 0 | For |
| Vanguard | 2,834,611 | 0 | 0 | 0 | For |
| Capital Group | 2,741,678 | 0 | 0 | 0 | For |
| BlackRock | 665,445 | 0 | 0 | 0 | For |
| Bridge Builder Trust | 485,827 | 0 | 0 | 0 | For |
| Charles Schwab | 382,140 | 0 | 0 | 0 | For |
| FRANKLIN STRATEGIC SERIES | 273,800 | 0 | 0 | 0 | For |
| DRIEHAUS MUTUAL FUNDS | 266,534 | 0 | 0 | 0 | For |
| State Street | 196,276 | 0 | 0 | 0 | For |
| Hartford | 189,381 | 0 | 0 | 0 | For |
| FINANCIAL INVESTORS TRUST | 0 | 0 | 166,327 | 0 | Abstain |
| T. Rowe Price | 135,686 | 0 | 0 | 0 | For |
| Principal | 0 | 0 | 133,433 | 0 | Abstain |
| Victory Capital | 123,032 | 0 | 0 | 0 | For |
| Equitable | 68,907 | 0 | 36,230 | 0 | For |
| RBB FUND, INC. | 26,005 | 0 | 51,844 | 0 | Abstain |
| Northwestern Mutual | 67,144 | 0 | 0 | 0 | For |
| Brinker Capital Destinations Trust | 50,698 | 0 | 0 | 0 | For |
| TRUST FOR PROFESSIONAL MANAGERS | 45,516 | 0 | 0 | 0 | For |
| Jackson National | 43,688 | 0 | 0 | 0 | For |
| Lincoln Financial | 29,700 | 0 | 0 | 0 | For |
| Global X | 23,744 | 0 | 0 | 0 | For |
| TIAA | 22,239 | 0 | 0 | 0 | For |
| Northern Trust | 22,194 | 0 | 0 | 0 | For |
| John Hancock | 21,553 | 0 | 0 | 0 | For |
Showing the 25 largest of 52 asset managers. See all 52 in the interactive database.
Combines 4 wordings of this item as funds reported it.
83% Majority: yes · of votes cast
SPYRE THERAPEUTICS INC.’s own tally for this item (“Elect Director: Peter Harwin”): 38,196,060 for, 7,977,323 withheld, per its Form 8-K filed 2025-06-02 (Item 5.07). FOR was more than half of the votes cast. Whether the item passed is for the filing to say; its statement has not been read for this item. Of all 60,275,561 outstanding shares: 63% for, 13% withheld (77% of the company cast a for/withheld vote).
The 52 asset managers below cast 100% of the shares they voted on this item FOR (13,697,468 for, 0 against).
| Asset manager | For | Against | Abstain | Withheld | Vote |
|---|---|---|---|---|---|
| Fidelity | 5,935,483 | 0 | 0 | 0 | For |
| Vanguard | 2,834,611 | 0 | 0 | 0 | For |
| Capital Group | 2,741,678 | 0 | 0 | 0 | For |
| BlackRock | 665,445 | 0 | 0 | 0 | For |
| Bridge Builder Trust | 17,631 | 0 | 468,196 | 0 | Abstain |
| Charles Schwab | 382,140 | 0 | 0 | 0 | For |
| FRANKLIN STRATEGIC SERIES | 273,800 | 0 | 0 | 0 | For |
| DRIEHAUS MUTUAL FUNDS | 0 | 0 | 266,534 | 0 | Abstain |
| State Street | 196,043 | 0 | 233 | 0 | For |
| Hartford | 189,381 | 0 | 0 | 0 | For |
| FINANCIAL INVESTORS TRUST | 0 | 0 | 166,327 | 0 | Abstain |
| T. Rowe Price | 135,686 | 0 | 0 | 0 | For |
| Principal | 0 | 0 | 133,433 | 0 | Abstain |
| Victory Capital | 12 | 0 | 123,020 | 0 | Abstain |
| Equitable | 105,137 | 0 | 0 | 0 | For |
| RBB FUND, INC. | 0 | 0 | 77,849 | 0 | Abstain |
| Northwestern Mutual | 67,144 | 0 | 0 | 0 | For |
| Brinker Capital Destinations Trust | 894 | 0 | 49,804 | 0 | Abstain |
| TRUST FOR PROFESSIONAL MANAGERS | 0 | 0 | 45,516 | 0 | Abstain |
| Jackson National | 0 | 0 | 43,688 | 0 | Abstain |
| Lincoln Financial | 29,700 | 0 | 0 | 0 | For |
| Global X | 23,744 | 0 | 0 | 0 | For |
| TIAA | 22,239 | 0 | 0 | 0 | For |
| Northern Trust | 0 | 0 | 22,194 | 0 | Abstain |
| John Hancock | 8,220 | 0 | 13,333 | 0 | Abstain |
Showing the 25 largest of 52 asset managers. See all 52 in the interactive database.
Combines 4 wordings of this item as funds reported it.
81% Majority: yes · of votes cast
SPYRE THERAPEUTICS INC.’s own tally for this item (“Elect Director: Sandra Milligan, M.D., J.D.”): 37,612,795 for, 8,560,588 withheld, per its Form 8-K filed 2025-06-02 (Item 5.07). FOR was more than half of the votes cast. Whether the item passed is for the filing to say; its statement has not been read for this item. Of all 60,275,561 outstanding shares: 62% for, 14% withheld (77% of the company cast a for/withheld vote).
The 52 asset managers below cast 100% of the shares they voted on this item FOR (13,455,733 for, 0 against).
| Asset manager | For | Against | Abstain | Withheld | Vote |
|---|---|---|---|---|---|
| Fidelity | 5,935,483 | 0 | 0 | 0 | For |
| Vanguard | 2,834,611 | 0 | 0 | 0 | For |
| Capital Group | 2,741,678 | 0 | 0 | 0 | For |
| BlackRock | 665,445 | 0 | 0 | 0 | For |
| Bridge Builder Trust | 17,631 | 0 | 468,196 | 0 | Abstain |
| Charles Schwab | 382,140 | 0 | 0 | 0 | For |
| FRANKLIN STRATEGIC SERIES | 273,800 | 0 | 0 | 0 | For |
| DRIEHAUS MUTUAL FUNDS | 0 | 0 | 266,534 | 0 | Abstain |
| State Street | 486 | 0 | 195,790 | 0 | Abstain |
| Hartford | 189,381 | 0 | 0 | 0 | For |
| FINANCIAL INVESTORS TRUST | 0 | 0 | 166,327 | 0 | Abstain |
| T. Rowe Price | 135,686 | 0 | 0 | 0 | For |
| Principal | 0 | 0 | 133,433 | 0 | Abstain |
| Victory Capital | 12 | 0 | 123,020 | 0 | Abstain |
| Equitable | 68,907 | 0 | 36,230 | 0 | For |
| RBB FUND, INC. | 0 | 0 | 77,849 | 0 | Abstain |
| Northwestern Mutual | 67,144 | 0 | 0 | 0 | For |
| Brinker Capital Destinations Trust | 0 | 0 | 50,698 | 0 | Abstain |
| TRUST FOR PROFESSIONAL MANAGERS | 0 | 0 | 45,516 | 0 | Abstain |
| Jackson National | 0 | 0 | 43,688 | 0 | Abstain |
| Lincoln Financial | 0 | 0 | 29,700 | 0 | Abstain |
| Global X | 23,744 | 0 | 0 | 0 | For |
| TIAA | 22,239 | 0 | 0 | 0 | For |
| Northern Trust | 22,194 | 0 | 0 | 0 | For |
| John Hancock | 8,220 | 0 | 13,333 | 0 | Abstain |
Showing the 25 largest of 52 asset managers. See all 52 in the interactive database.
99.8% Majority: yes · of votes cast
SPYRE THERAPEUTICS INC.’s own tally for this item (“Proposal 3: The Company's stockholders ratified the appointment of KPMG LLP as the Company's independent registered public accounting firm for the year ending December 31, 2025.”): 49,227,863 for, 57,123 against, per its Form 8-K filed 2025-06-02 (Item 5.07). FOR was more than half of the votes cast. Whether the item passed is for the filing to say; its statement has not been read for this item. Of all 60,275,561 outstanding shares: 82% for, 0.1% against (82% of the company cast a for/against vote).
The 52 asset managers below cast 99.9% of the shares they voted on this item FOR (15,204,611 for, 585 against).
| Asset manager | For | Against | Abstain | Withheld | Vote |
|---|---|---|---|---|---|
| Fidelity | 5,935,483 | 0 | 0 | 0 | For |
| Vanguard | 2,834,611 | 0 | 0 | 0 | For |
| Capital Group | 2,741,678 | 0 | 0 | 0 | For |
| BlackRock | 665,445 | 0 | 0 | 0 | For |
| Bridge Builder Trust | 485,827 | 0 | 0 | 0 | For |
| Charles Schwab | 382,140 | 0 | 0 | 0 | For |
| FRANKLIN STRATEGIC SERIES | 273,800 | 0 | 0 | 0 | For |
| DRIEHAUS MUTUAL FUNDS | 266,534 | 0 | 0 | 0 | For |
| State Street | 196,276 | 0 | 0 | 0 | For |
| Hartford | 189,381 | 0 | 0 | 0 | For |
| FINANCIAL INVESTORS TRUST | 166,327 | 0 | 0 | 0 | For |
| T. Rowe Price | 135,686 | 0 | 0 | 0 | For |
| Principal | 133,433 | 0 | 0 | 0 | For |
| Victory Capital | 123,032 | 0 | 0 | 0 | For |
| Equitable | 105,137 | 0 | 0 | 0 | For |
| RBB FUND, INC. | 77,849 | 0 | 0 | 0 | For |
| Northwestern Mutual | 67,144 | 0 | 0 | 0 | For |
| Brinker Capital Destinations Trust | 50,698 | 0 | 0 | 0 | For |
| TRUST FOR PROFESSIONAL MANAGERS | 45,516 | 0 | 0 | 0 | For |
| Jackson National | 43,688 | 0 | 0 | 0 | For |
| Lincoln Financial | 29,700 | 0 | 0 | 0 | For |
| Global X | 23,744 | 0 | 0 | 0 | For |
| TIAA | 22,239 | 0 | 0 | 0 | For |
| Northern Trust | 22,194 | 0 | 0 | 0 | For |
| John Hancock | 21,553 | 0 | 0 | 0 | For |
Showing the 25 largest of 52 asset managers. See all 52 in the interactive database.
Ranked by the number of SPYRE THERAPEUTICS INC. shares each manager voted on the most widely held ballot item of the 2024-2025 meeting, shown as a share of the 60,275,561 shares outstanding at the time of that meeting.
| # | Asset manager | % of shares outstanding |
|---|---|---|
| 1 | Fidelity | 22.56% |
| 2 | Capital Group | 9.10% |
| 3 | Fairmount Funds Management LLC | 6.67% |
| 4 | RTW INVESTMENTS, LP | 5.95% |
| 5 | Vanguard | 4.86% |
| 6 | DRIEHAUS CAPITAL MANAGEMENT LLC | 3.08% |
| 7 | BlackRock | 2.68% |
| 8 | PERCEPTIVE ADVISORS LLC | 2.18% |
| 9 | BRAIDWELL LP | 1.89% |
| 10 | GEODE CAPITAL MANAGEMENT, LLC | 1.74% |
Positions disclosed to the SEC on Schedules 13D and 13G, Form 13F and the company’s own proxy statement (DEF 14A).
| Holder | % outstanding | Disclosure |
|---|---|---|
| FMR (Fidelity) | 15.00% | 13F |
| Peter Harwin | 14.96% | 13D |
| FMR LLC | 12.65% | DEF14A |
| Tomas Kiselak | 11.18% | DEF14A |
| Fairmount Healthcare Fund II L.P. | 10.36% | DEF14A |
| Perceptive Advisors LLC | 7.17% | 13G |
| RTW Investments, LP | 6.01% | 13G |
| BlackRock | 5.93% | 13F |
| Peter Deutsch | 5.89% | DEF14A |
| Vanguard Group | 4.81% | 13F |
Percentages above are of 60,275,561 shares outstanding, as reported by SPYRE THERAPEUTICS INC. on its Form 10-Q dated 2025-03-31 (see the filing on EDGAR). This is the count contemporaneous with the 2024-2025 meeting, so the percentages are the ones that were true then, not ones restated against today’s share count.
Every figure above is derived from filings made with the US Securities and Exchange Commission: Form N-PX, in which registered investment companies and institutional managers disclose how they voted every proxy, and Form 8-K Item 5.07, in which the company reports its own meeting results. Shares outstanding are taken from SPYRE THERAPEUTICS INC.’s 10-Q dated 2025-03-31. This page is a static snapshot rebuilt weekly on 04 October 2026; a live search always shows the current data.
At SPYRE THERAPEUTICS INC.'s shareholder meeting held 2025-05-29, in the 2024-2025 proxy season, 152 asset managers reported how they voted on 5 ballot items in their SEC Form N-PX filings, covering 942 separate fund positions. On the most widely held item on that ballot — TO APPROVE, ON A NON-BINDING, ADVISORY BASIS, THE COMPENSATION OF THE COMPANY'S NAMED EXECUTIVE… — FOR was 93% of the votes cast (FOR divided by FOR plus AGAINST, the conventional basis for proxy support; abstentions, broker non-votes and unvoted shares are excluded because none of them took a side), which is more than half. Whether the item was approved is for the filing to say; that statement has not been read for this item. Source: SPYRE THERAPEUTICS INC.'s Form 8-K, Item 5.07, filed with the U.S. Securities and Exchange Commission on 2025-06-02.
SPYRE THERAPEUTICS INC. proxy season coverage: 2024-2025 (this page) · 2025-2026.